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What is Intrahepatic Ectopic Pregnancy: Latest Case, Symptoms, Risks & Treatments

Published by Vishesh Hospital

intrahepatic ectopic pregnancy

Intrahepatic ectopic pregnancy is one of the rarest forms of ectopic pregnancy, where a fertilized egg implants within the liver, rather than the uterus or fallopian tubes. Globally, fewer than eight cases have ever been documented, and its medical implications are extraordinarily severe due to the liver’s dense blood supply and lack of structural support for pregnancy.

India’s First Documented Case (2025)

In July 2025, doctors in Bulandshahr, Uttar Pradesh, diagnosed a 30-year-old woman with intrahepatic ectopic pregnancy—the first known case in India. After weeks of abdominal pain and vomiting, routine ultrasounds failed to reveal the cause. An MRI scan uncovered a live, 12-week-old foetus “embedded in the right lobe of her liver,” with active cardiac pulsations and an empty uterus.

A multidisciplinary team, including radiologists, obstetricians, and hepatobiliary surgeons, acted swiftly, planning emergency surgery to save the patient’s life and manage this potentially fatal condition. In such cases, the primary medical goal is always to preserve maternal health.

Global Rarity and Medical Relevance

  • Only eight cases have ever been reported worldwide, in countries including the United States, China, Nigeria, and now India.

  • Intrahepatic implantation is a medical phenomenon, representing about 0.03% of all ectopic pregnancies.

  • Ectopic pregnancies most commonly (97%) occur in the fallopian tubes, making hepatic forms exceptionally rare and dangerous.

Symptoms & Risk Factors

       Typical Symptoms

  • Persistent abdominal pain, especially in the upper abdomen

  • Severe or unusual vomiting

  • Weakness, fatigue, and dizziness

  • Abnormal vaginal bleeding

  • No relief from routine pain management

       Risk Factors

  • Prior ectopic pregnancy

  • Pelvic inflammatory disease

  • Previous abdominal surgery

  • Use of assisted reproductive technologies
    However, intrahepatic cases may occur without classic risk factors—delaying discovery.

Modern Diagnostic Approaches

High-resolution imaging

  • MRI and CT scans are essential as routine ultrasound may miss intrahepatic gestational sacs.

  • Detailed blood tests confirm elevated hCG pregnancy hormone levels.

Clinical suspicion

  • Persistent pain and ambiguous tests require specialist involvement and advanced imaging for confirmation.

Treatment & Management Strategies

1. Emergency Surgical Removal

  • Open or laparoscopic surgery may be required.

  • Sometimes partial liver resection is necessary to prevent fatal internal bleeding.

2. Use of Methotrexate

  • In select stable cases, methotrexate medication can help dissolve pregnancy tissue, reducing bleeding risk before surgery.

3. Post-Op Monitoring

  • Intensive care for bleeding, infection, and liver function

  • Monitoring hCG to confirm resolution

4. Multidisciplinary Care

  • Collaboration among obstetric, hepatobiliary, and anesthesia teams is critical for success.

Latest Research & Case Studies

  • India’s 2025 Case:
    First documented live intrahepatic pregnancy in India led to rapid emergency intervention; now being studied for future guidance.

  • Global Incidence:
    Only seven similar cases reported previously in literature; all involve multidisciplinary management and highlight the need for prompt diagnosis.

  • Systematic Reviews:
    Modern reviews suggest methotrexate may precede surgery, reducing blood loss; however, most cases still require surgical intervention due to hemorrhagic risk.

FAQs - Intrahepatic Ectopic Pregnancy

1. What makes intrahepatic ectopic pregnancy so dangerous?

The liver’s rich blood supply means any rupture or surgery can cause catastrophic internal bleeding, threatening maternal life.

2. Can the pregnancy continue until birth?

No. The liver cannot support foetal development—these cases always require termination to save the mother.

3. How is it diagnosed?

High-resolution MRI or CT scans and blood hormone tests are essential—routine ultrasounds may not suffice.

4. What are the symptoms to watch for?

Upper abdominal pain, vomiting, weakness and unexplained bleeding—especially when routine scans are inconclusive.

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Don’t let gynecological issues impact your well-being. At Vishesh Hospital, our expert gynecology services in Nagpur provide compassionate care for every stage of a woman’s life. Whether you’re facing menstrual irregularities, planning a pregnancy, or need advanced treatment, our experienced team is here to support your health with confidence and care.